Little is known about their presence and dynamics in blood after trauma, and nothing is known about Treg in the porcine polytrauma model. Regulatory T cells (Treg play a key role in the suppression of the immune response and in the maintenance of immunological homeostasis. PMID:26170533Ĭomparative Analysis of the Regulatory T Cells Dynamics in Peripheral Blood in Human and Porcine Polytraumaįull Text Available BackgroundSeverely injured patients experience substantial immunological stress in the aftermath of traumatic insult, which often results in systemic immune dysregulation. ![]() Future studies should extend therapeutic hypothermia. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. But the chosen length for therapeutic hypothermia was too short. Therapeutic hypothermia revealed hints for tissue protective impact. No major harmful effects on hemodynamics were observed. Induced hypothermia after polytrauma is feasible. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Induced hypothermia had neither harmful nor major positive effects on the animals' hemodynamics. Resuscitation showed adequate restoration of hemodynamics. ![]() Our polytrauma porcine model displayed sufficient trauma impact. We documented cardiovascular parameters and basic respiratory parameters. Therapeutic hypothermia (34Â☌) was induced for 3 hours. We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. The deterioration of hemodynamics instantly endangers the patients' life after polytrauma. Mommsen, Philipp Pfeifer, Roman Mohr, Juliane Ruchholtz, Steffen Flohé, Sascha Fröhlich, Matthias Keibl, Claudia Seekamp, Andreas Witte, Ingoīackground. ![]() Induced hypothermia had neither harmful nor major positive effects on the animals’ hemodynamics. Therapeutic hypothermia (34Â☌ was induced for 3 hours. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Modelĭirectory of Open Access Journals (Sweden)įull Text Available Background.
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